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DIPEPTIDYL AMINOPEPTIDASE I
Descriptors Found:
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DeCS
Descriptor
English
:
Cathepsin C
Descriptor
Spanish
:
catepsina C
Descriptor
Portuguese
:
Catepsina C
Synonyms
English
:
Dipeptidyl Aminopeptidase I
Dipeptidyl Peptidase I
Dipeptidyl Transferase
Tree Number:
D08.811.277.656.224.130
D08.811.277.656.262.186
D08.811.277.656.350.350.100
Definition
English
:
A papain-like
cysteine
protease that has specificity for amino terminal
dipeptides
. The enzyme plays a role in the activation of several pro-inflammatory
serine proteases
by removal of their aminoterminal inhibitory
dipeptides
. Genetic
mutations
that cause loss of
cathepsin C
activity in
humans
are associated with
PAPILLON-LEFEVRE DISEASE.
History Note
English
:
2010(1981)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
34436
Unique Identifier:
D020789
Occurrence in VHL
:
Similar:
DeCS